Efficacy Analysis of the Treatment of Grade 3 Diabetic Foot Cases by Minimally Invasive Toe-preserving Combined with Regenerative Medical Technology

DOI: https://doi.org/10.62517/jmhs.202505202

Author(s)

Rui Jiao, Ronghai Zhou, Yanchun He, Decai Kong, Yiman Shen, Na Song

Affiliation(s)

People's Hospital of Hainan District, Wuhai, Inner Mongolia, China

Abstract

This study delves into the research conducted by the Hainan District People's Hospital in Wuhai City on the application of regenerative medical technology in the treatment of chronic refractory wounds, with a specific focus on a case study involving toe-preserving therapy for diabetic foot. The treatment protocol adopted a combined approach of minimally invasive surgery and regenerative medical technology for toe preservation in diabetic foot cases. The significance of this research lies in the application of this integrated strategy, which utilizes minimally invasive techniques alongside regenerative medical technology to treat diabetic foot wounds. This approach ensures hemostasis, prevents damage to normal tissues and blood vessels, avoids reperfusion injury, and accelerates wound healing. After 45 days of treatment, the stability, integrity, and aesthetic appearance of the patient's left fifth toe were successfully preserved.

Keywords

Minimally Invasive; Regenerative Medical Technology; Grade 3 Diabetic Foot; Rifampicin; Moist Exposed Burn Ointment

References

[1] Zheng Chen, Wenhu Li, Hongmei Deng, et al. Efficacy Analysis of Combined Treatment with Multiple Techniques for Wagner Grade 3-5 Diabetic Foot. Chinese Journal of Burns, Wounds and Surface Ulcers, 2022, 34(6): 389-400. [2] Chunyu Li, Xiaoming Liu, Xiaopei Li, et al. Research Progress of Platelet-rich Fibrin in the Treatment of Diabetic Foot. Chinese Journal of Burns, Wounds and Surface Ulcers, 2025, 37(1): 18-21. [3] Guanghua Guo, Feng Zhu, Dinghong Min, et al. National Expert Consensus on the Surgical Treatment of Diabetic Foot Complicated with Difficult-to-heal Wounds (2020 Edition). Chinese Journal of Injury Repair and Wound Healing (Electronic Edition), 2020, 15(4): 256-263. [4] Fei Lu, Runlin Jin, Haoqiang Shi. Evaluation and Analysis of Off-label Use of Rifampicin. Chinese Journal of Clinical Physicians, 2021, 49(1): 28-30. [5] STETTLER R, TRAMPUZ A. The “Second Life” of Rifampicin. Rev Med Suisse, 2014, 10(422): 670-672. [6] ZHOU X, YANG D, KONG X, et al. Pirfenidone in the Treatment of Post-COVID-19 Pulmonary Fibrosis. Front Med (Lausanne), 2022, 9: 925703. [7] Pingxia Jiang. Topical Application of Rifampicin Combined with Chloramphenicol in the Treatment of Infections of Difficult-to-heal Wounds. Zhejiang Journal of Integrated Traditional Chinese and Western Medicine, 2003, 13(5): 318-319. [8] Xiuying Gao, Wenfang Cai, Xu Hao. Clinical Observation of Topical Application of Rifampicin in the Treatment of 53 Cases of Pressure Sores. Journal of Harbin Medical University, 2009, 43(6): 624-625. [9] Chao Xiong, Qiang Chen. Effect of Moist Exposed Burn Ointment Combined with Negative Pressure Therapy on Diabetic Necrotizing Fasciitis and Its Influence on the Levels of Inflammatory Factors. Inner Mongolia Journal of Traditional Chinese Medicine, 2021, 3(3): 114-115. [10] Xiaoning Cen, Qianli Tang, Chenyi Zhuo, et al. Research Progress on the Mechanism of Action of MEBT/MEBO in the Treatment of Diabetic Foot. Chinese Journal of Burns, Wounds and Surface Ulcers, 2023, 35(1): 1-4. [11] Yuhong Zheng, Yongchong Chen, Zhiying Wang, et al. Clinical Study on the Technology of Burn Regenerative Medicine in Controlling Burn Wound Infection. Chinese Journal of Burns, Wounds and Surface Ulcers, 2012, 24(6): 432-438. [12] Chuanxing Lin, Jianchong Chen, Jiaxin Huang, et al. Efficacy of Moist Exposed Burn Ointment Combined with PRP in the Treatment of Diabetic Foot Ulcers. Medical Innovation of China, 2025, 22(7): 60-63. [13] Qianli Tang, Jiehui Li. Expert Consensus on the Standardized Application of Skin Regenerative Medical Technology in the Staged and Graded Diagnosis and Treatment of Diabetic Wounds. Chinese Journal of Burns, Wounds and Surface Ulcers, 2021, 33(5): 310-316. [14] Kaiyan Li, Yucheng He, Dingpeng Zhou, et al. Exploring the Mechanism of Action of Moist Exposed Burn Ointment in the Treatment of Diabetic Foot Based on Bioinformatics Technology. Clinical Medicine Research and Practice, 2024, 2, 9(4): 16-20. [15] TANG Q L, HAN S S, FENG J, et al. Moist Exposed Burn Ointment Promotes Cutaneous Excisional Wound Healing in Rats Involving VEGF and bFGF. Mol Med Rep, 2014, 9(4): 1277-1282.