Study on the Effect of TLR4/NF-κB Mediated by Resolving Turbidity and Lowering Lipids Tea on the Inflammatory State of Damp-Heat-Internalised Hyperlipidaemia_Vol. 3 No. 2 (JMHS 2025)_Journal of Medicine and Health Science (ISSN: 2959-0639)

Home > Journal of Medicine and Health Science (ISSN: 2959-0639) > Vol. 3 No. 2 (JMHS 2025) >

Study on the Effect of TLR4/NF-κB Mediated by Resolving Turbidity and Lowering Lipids Tea on the Inflammatory State of Damp-Heat-Internalised Hyperlipidaemia

Download PDF

DOI: https://doi.org/10.62517/jmhs.202505210

Author(s)

Ling Chen, Jun Su*, Jibin Huang, Siya Xu, Yuzhu Zhan

Affiliation(s)

Qiannan Prefecture Traditional Chinese Medicine Hospital, Duyun, China *Corresponding Author

Abstract

This study evaluates the lipid-lowering efficacy, anti-inflammatory properties, and safety of Huazhuo Jiangzhi Tea, a herbal formulation comprising Crataegus pinnatifida, Gynostemma pentaphyllum, and Cassia obtusifolia, in 80 hyperlipidemia patients with damp-heat internal retention syndrome. Participants were randomized to receive either the herbal tea or atorvastatin (20 mg/day) for 4 weeks, with assessments of lipid profiles, inflammatory biomarkers, oxidative stress markers, and traditional Chinese medicine (TCM) syndrome scores. Post-treatment, the herbal tea group exhibited significantly greater reductions in triglycerides (1.55±0.13 vs. 1.83±0.14), total cholesterol (5.01±0.56 vs. 6.14±0.47), and LDL-C (3.03±0.24 vs. 3.60±0.14), alongside enhanced antioxidant activity (SOD: 89.75±6.11 vs. 87.16±4.72) and marked suppression of inflammatory mediators (CRP, TLR4, MCP-1, TNF-α, IL-6, sVCAM-1, NF-κB). TCM symptom scores improved more substantially in the treatment group (8.93±4.60 vs. 12.00±5.27), with comparable safety profiles to statin therapy. These findings demonstrate that Huazhuo Jiangzhi Tea effectively modulates lipid metabolism and inflammation through potential TLR4/NF-κB pathway regulation, offering a multi-target herbal approach for managing hyperlipidemia with damp-heat syndrome.

Keywords

Huazhuo Jiangzhi Tea; Damp - Heat Internal Accumulation; Hyperlipidemia with Inflammation; TLR4/NF – κB

References

[1]Wang Yongyan, Wang Qi. Internal Medicine of Traditional Chinese Medicine. Beijing: People's Medical Publishing House, 2011. [2]Li Dexin Basic Theory of Traditional Chinese Medicine. Beijing: People's Medical Publishing House, 2006. [3]She Yiming, Hu Yonghui, Zhang Liye, et al. Research Progress on Lipid Regulation with Traditional Chinese Medicine. Chinese Traditional and Herbal Drugs, 2017, (17): 3636-3644 [4]Qin Jian, Feng Jinwu. Research Progress on the Treatment of Hyperlipidemia with Traditional Chinese Medicine. World Journal of Integrated Traditional and Western Medicine, 2016, (11): 1607-1609+1614.. [5]Wang J, Guo LL, Wang YY. [Study on combination components and effectiveness of Chinese traditional herbal formulas]. Zhongguo Zhong Yao Za Zhi. 2006 Jan;31(1):5-9. [6]Zhu Junren, Gao Runlin, Zhao Shuiping, et al. Guidelines for the Prevention and Treatment of Dyslipidemia in Chinese Adults (Revised Edition 2016). Chinese Circulation Journal, 2016, (10): 937-953. [7]Wang Zhenmin, Luo Jianquan, Zhang Wei. Research Progress on the Correlation between LRP6 Gene Polymorphism and Metabolic Syndrome. Chinese Pharmacological Bulletin, 2016, (05): 603-607.. [8]Li Jianchao, Jiang Shengnan, Wu Jiahui, et al. Research Progress of Traditional Chinese Medicine in the Treatment of Hyperlipidemia. China's Naturopathy, 2024, (23): 100-103. [9]Liang Hao, Li Yonghua, Zhao Na, et al. Research progress on the Lipid-lowering Mechanism of Active Components in Hawthorn. Jiangsu Journal of Traditional Chinese Medicine: 1-4. [10]Wang N., Li C., Zhang Z. Arctigenin ameliorates high-fat diet-induced metabolic disorders by reshaping gut microbiota and modulating GPR/HDAC3 and TLR4/NF-κB pathways. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2024, 135: 156123. [11]Li Li, Huang Minjiang, Lu Xiaomin, et al. Research Progress of Gynostemma Pentaphyllum and its Active Components in the Treatment of Cardiovascular Diseases. RENSHEN YANJIU, 2025, (01): 77-80. [12]Yuan Youcai, Li Liheng, Li Yan, et al. Research Progress on Chemical Components and Pharmacological Effects of Cassia Seed. Journal of Liaoning University of Traditional Chinese Medicine: 1-16. [13]Hotamisligil G.S. Inflammation, metaflammation and immunometabolic disorders. Nature, 2017, 542(7640): 177-185. [14]Libby P., Ridker P.M., Hansson G.K. Inflammation in atherosclerosis: from pathophysiology to practice. Journal of the American College of Cardiology, 2009, 54(23): 2129-2138. [15]Lee B, Shim I, Lee H, Hahm DH. Gypenosides attenuate lipopolysaccharide-induced neuroinflammation and anxiety-like behaviors in rats. Anim Cells Syst (Seoul). 2018 Sep 5;22(5):305-316. doi: 10.1080/19768354.2018.1517825. [16]Dong Hao, Ku Yabei, Wang Weipeng, et al. Research progress on Extraction Methods and pharmacological Effects of Total Flavonoids from Hawthorn. Studies of Trace Elements and Health, 2025, (01): 66-70. [17]Ma Yong, Zhao Bin, Wang Minggang, et al. Anthraquinone glycosides of Cassia seed inhibit myocardial injury in rats with coronary heart disease through the Nrf2/ARE signaling pathway. hinese Journal of Histochemistry and Cytochemistry, 2022, (06): 565-574. [18]Yen GC, Chung DY. Antioxidant effects of extracts from Cassia tora L. prepared under different degrees of roasting on the oxidative damage to biomolecules. J Agric Food Chem. 1999 Apr;47(4):1326-32. doi: 10.1021/jf9810618. [19]Witkowski M., Weeks T.L., Hazen S.L. Gut Microbiota and Cardiovascular Disease. Circulation research, 2020, 127(4): 553-570. Li H.Y., Zhou D.D., Gan R.Y. et al. Effects and Mechanisms of Probiotics, Prebiotics, Synbiotics, and Postbiotics on Metabolic Diseases Targeting Gut Microbiota: A Narrative Review. Nutrients, 2021, 13(9)