Study on the Anti-Inflammatory and Analgesic Effects of Mongolian Medicine Maqianzi-2

DOI: https://doi.org/10.62517/jmpe.202618116

Author(s)

Xiaohong Bai1,2, #, Ruhan A3,4, #, Munkhjargal Nyamjav5, Biligetu Wang6, Meng Meng2, Tegexibayin Wang3,4*, Lan Wu2,*

Affiliation(s)

1College of Mongolian Medicine, Inner Mongolia Minzu University, Tongliao, China 2College of Mongolian Medicine, Inner Mongolia Medical University, Hohhot, China 3Affiliated Hospital, Inner Mongolia Minzu University, Tongliao, China 4Laboratory of Medical Research and Innovation Center, Tongliao, China 5Otoch Manramba University, Ulaanbaatar, Mongolia 6College of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China *Corresponding Author #Xiaohong Bai and Ruhan A contribute equally to this work.

Abstract

This study aims to evaluate the anti-inflammatory and analgesic properties of Mongolian Medicine Maqianzi-2 (MM-2) through the use of a 1% carrageenan-induced rat paw edema model and the hot plate test in mice. Seventy-two Sprague-Dawley rats were randomly assigned to a blank control group, vehicle control group, positive control group, and low, medium, and high dosage MM-2 groups. Following continuous administration, paw volume was measured to assess the inhibition of swelling. Additionally, eighty-four Kunming mice were divided similarly for dosing, with pain thresholds recorded at various time points to analyze analgesic effects. Results from the anti-inflammatory assay demonstrated that the low-dose MM-2 group and the positive control significantly suppressed paw edema at 0.5 and 1 hour post-inflammation induction (P<0.05), while the medium-dose group also showed an inhibitory trend, the difference was not statistically significant. In the analgesic test, the low-dose MM-2 group markedly elevated pain thresholds at 1 hour post-administration (P<0.01), whereas no significant differences were observed at other time points or in the medium- and high-dose groups. Transdermal application of MM-2 effectively attenuates carrageenan-induced rat paw edema and enhances pain thresholds in mice, manifesting pronounced anti-inflammatory and analgesic activities.

Keywords

Mongolian Medicine Maqianzi-2; Anti-inflammatory Effect; Analgesic Effect

References

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